Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC7092858 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yu Xiao X Chen Shuliang S Hou Panpan P Wang Min M Chen Yu Y Guo Deyin D
Biochemical and biophysical research communications 20150228 2
Eukaryotic cellular and most viral RNAs carry a 5'-terminal cap structure, a 5'-5' triphosphate linkage between the 5' end of the RNA and a guanosine nucleotide (cap-0). SARS coronavirus (SARS-CoV) nonstructural protein nsp16 functions as a methyltransferase, to methylate mRNA cap-0 structure at the ribose 2'-O position of the first nucleotide to form cap-1 structures. However, whether there is interplay between nsp16 and host proteins was not yet clear. In this report, we identified several pot ...[more]