Ontology highlight
ABSTRACT:
SUBMITTER: Sousounis K
PROVIDER: S-EPMC7093111 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
eLife 20200306
How salamanders accomplish progenitor cell proliferation while faithfully maintaining genomic integrity and regenerative potential remains elusive. Here we found an innate DNA damage response mechanism that is evident during blastema proliferation (early- to late-bud) and studied its role during tissue regeneration by ablating the function of one of its components, Eyes absent 2. In <i>eya2</i> mutant axolotls, we found that DNA damage signaling through the H2AX histone variant was deregulated, ...[more]