Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.
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ABSTRACT:
SUBMITTER: Cuellar J
PROVIDER: S-EPMC7093131 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.
Cuellar Julia J Åstrand Mia M Elovaara Heli H Pietikäinen Annukka A Sirén Saija S Liljeblad Arto A Guédez Gabriela G Salminen Tiina A TA Hytönen Jukka J
Infection and immunity 20200323 4
<i>Borrelia burgdorferi</i><i>sensu lato</i>, the causative agent of tick-borne Lyme borreliosis (LB), has a limited metabolic capacity and needs to acquire nutrients, such as amino acids, fatty acids, and nucleic acids, from the host environment. Using X-ray crystallography, liquid chromatography-mass spectrometry, microscale thermophoresis, and cellular localization studies, we show that basic membrane protein D (BmpD) is a periplasmic substrate-binding protein of an ABC transporter system bin ...[more]
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