Measures of Adipose Tissue Redistribution and Atherosclerotic Coronary Plaque in HIV.

ABSTRACT: OBJECTIVE:People with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD). The relationship between adipose compartments and coronary disease is not well understood among PWH. METHODS:A total of 148 PWH and 68 uninfected individuals without CVD were well phenotyped for VAT and SAT via single-section abdominal computed tomography (CT) at L4. Coronary artery calcium (CAC) score was assessed by noncontrast cardiac CT and coronary plaque composition by coronary CT angiography. RESULTS:Increased VAT was significantly related to increased presence of plaque (OR, 1.55 per 100 cm2 ; P?=?0.008) and CAC?>?0 (OR, 1.56 per 100 cm2 ; P?=?0.006) in the HIV group. In contrast, increased SAT was related to reduced presence of plaque (OR, 0.79 per 100 cm2 ; P?=?0.057) and reduced CAC?>?0 (OR, 0.69 per 100 cm2 , P?=?0.007) among PWH. The VAT to SAT ratio showed a strong relationship to overall presence of calcified plaque (OR, 3.30; P?=?0.03) and CAC?>?0 (OR, 3.57; P?

SUBMITTER: Bogorodskaya M 

PROVIDER: S-EPMC7093223 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature