Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar TJ
PROVIDER: S-EPMC7093390 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200324 1
Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis. Nuclear reprogramming to pluripotency can revert both the age and the identity of any cell to that of an embryonic cell. Recent evidence shows that transient repr ...[more]