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Single-Stage Arthroscopic Autologous Matrix-Enhanced Chondral Transplantation (AMECT) in the Hip.

ABSTRACT: Chondral defects of the acetabulum in patients with femoroacetabular impingement syndrome are an increasingly recognized cause of worse outcomes after treatment. Multiple procedures have been described for the treatment of hip cartilage lesions including microfracture, autologous chondrocyte implantation, matrix-induced autologous chondrocyte implantation, and autograft and allograft transplantation. However, many of these techniques have poor long-term outcomes, require multiple surgical procedures, or rely on planned preoperative identification of the chondral lesion. This Technical Note describes our technique of autologous matrix-enhanced chondral transplantation, a single-stage treatment for acetabular cartilage lesions that harvests chondral tissue from the femoral cam deformity and combines it with chondral extracellular matrix, growth factors, and autologous peripheral blood.

SUBMITTER: Craig MJ

PROVIDER: S-EPMC7093729 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Arthroscopic Microfracture of Hip Chondral Lesions.

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Clinical Outcomes of an All-Arthroscopic Technique for Single-Stage Autologous Matrix-Induced Chondrogenesis in the Treatment of Articular Cartilage Lesions of the Knee.

Project description:PurposeThe purpose of this study was to determine the clinical efficacy of an all-arthroscopic approach to autologous matrix-induced chondrogenesis (AMIC) for patients with articular cartilage lesions of the knee joint. We hypothesize that an all-arthroscopic, single-stage AMIC using a hyaluron-based cell-free scaffold improves the postoperative clinical scores for patients with isolated articular cartilage lesions of the knee in the early follow-up period.MethodsAll patients with focal osteochondral lesions of the knee treated with AMIC at our institution from November 2013 to January 2018 were included for analysis. Demographic information, baseline clinical characteristics, perioperative imaging, and follow-up International Knee Documentation Committee (IKDC) scores at 6 and 24 months postoperatively were collected. One-way analysis of variance (ANOVA) with a Bonferroni correction was used to assess for improvement before and after surgery, with statistical significance defined as p < .05.ResultsA total of 22 patients met the inclusion criteria and were analyzed for this study. Articular cartilage lesions were most commonly found at the center of the medial and lateral femoral condyles. Statistically significant improvements in IKDC scores were seen at the 6- and 24-month follow-up periods (p < .05).ConclusionAn all-arthroscopic technique for single-stage autologous matrix-induced chondrogenesis demonstrates significant early clinical improvement for the treatment of articular cartilage lesions of the knee.Level of evidence4.

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