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Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.


ABSTRACT: In the related research article, entitled "Identification of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors endowed with antiproliferative and antiinflammatory activity" [1], we reported the in vitro hepatic metabolism data for compounds 30c, 48b, and 31b (here named as E5, A6, and T1), in comparison with the reference compounds GPP78 and FK866 [1-3]. In this article, we retrieved the available data about the hepatic microsomal stability and metabolites structural characterization of the entire library of triazole-based NAMPT inhibitors, also implementing the given information with data regarding aqueous solubility and CYP inhibition. Compounds are divided in subclasses based on the hydrolytic resistant groups replacing the amide function of GPP78 [1, 2].

SUBMITTER: Aprile S 

PROVIDER: S-EPMC7093798 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

Aprile Silvio S   Galli Ubaldina U   Tron Gian Cesare GC   Del Grosso Erika E   Travelli Cristina C   Grosa Giorgio G  

Data in brief 20191220


In the related research article, entitled "Identification of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors endowed with antiproliferative and antiinflammatory activity" [1], we reported the <i>in vitro</i> hepatic metabolism data for compounds 30c, 48b, and 31b (here named as <b>E5</b>, <b>A6</b>, and <b>T1</b>), in comparison with the reference compounds GPP78 and FK866 [1-3]. In this article, we retrieved the available data about the hepatic microsomal stabilit  ...[more]

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