Ontology highlight
ABSTRACT:
SUBMITTER: Yang G
PROVIDER: S-EPMC7094838 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yang Guang G Zhang Min M Zhao Yawei Y Pan Yue Y Kan Mujie M Li Jing J He Kan K Zhang Xuewen X
PloS one 20200325 3
Hepatocellular carcinoma (HCC) is one of the most common human cancers, its prevalence and severity need us to discover novel early diagnostic biomarkers and new therapeutic strategies. MicroRNA-122 is the most abundant microRNA in the liver, and acts as a tumor suppressor and represses HCC development. In our study we showed that HNF-4α and MiR-122 were down-regulated significantly in hepatocellular carcinoma. Over-expression of HNF-4α inhibit hepatocellular carcinoma cells proliferation. And m ...[more]