The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death.

ABSTRACT: NR4A is a nuclear receptor protein family whose members act as sensors of cellular environment and regulate multiple processes such as metabolism, proliferation, migration, apoptosis, and autophagy. Since the ligand binding domains of these receptors have no cavity for ligand interaction, their function is most likely regulated by protein abundance and post-translational modifications. In particular, NR4A1 is regulated by protein abundance, phosphorylation, and subcellular distribution (nuclear-cytoplasmic translocation), and acts both as a transcription factor and as a regulator of other interacting proteins. SUMOylation is a post-translational modification that can affect protein stability, transcriptional activity, alter protein-protein interactions and modify intracellular localization

SUBMITTER: Zarraga-Granados G 

PROVIDER: S-EPMC7094859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature