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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.


ABSTRACT: Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) 2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.

SUBMITTER: Zhou P 

PROVIDER: S-EPMC7094983 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

Zhou Peng P   Fan Hang H   Lan Tian T   Yang Xing-Lou XL   Shi Wei-Feng WF   Zhang Wei W   Zhu Yan Y   Zhang Ya-Wei YW   Xie Qing-Mei QM   Mani Shailendra S   Zheng Xiao-Shuang XS   Li Bei B   Li Jin-Man JM   Guo Hua H   Pei Guang-Qian GQ   An Xiao-Ping XP   Chen Jun-Wei JW   Zhou Ling L   Mai Kai-Jie KJ   Wu Zi-Xian ZX   Li Di D   Anderson Danielle E DE   Zhang Li-Biao LB   Li Shi-Yue SY   Mi Zhi-Qiang ZQ   He Tong-Tong TT   Cong Feng F   Guo Peng-Ju PJ   Huang Ren R   Luo Yun Y   Liu Xiang-Ling XL   Chen Jing J   Huang Yong Y   Sun Qiang Q   Zhang Xiang-Li-Lan XL   Wang Yuan-Yuan YY   Xing Shao-Zhen SZ   Chen Yan-Shan YS   Sun Yuan Y   Li Juan J   Daszak Peter P   Wang Lin-Fa LF   Shi Zheng-Li ZL   Tong Yi-Gang YG   Ma Jing-Yun JY  

Nature 20180404 7700


Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health <sup>1</sup> . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) <sup>2-10</sup> . Here we provide virological, epidemiological, evolutionary and experim  ...[more]

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