Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.
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ABSTRACT:
SUBMITTER: Yin HS
PROVIDER: S-EPMC7095149 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Publications
Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.
Yin Hsien-Sheng HS Wen Xiaolin X Paterson Reay G RG Lamb Robert A RA Jardetzky Theodore S TS
Nature 20060101 7072
Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of viral and cellular membranes, permitting entry of the viral genome into the cell. For the paramyxoviruses, the fusion (F) protein catalyses this membrane merger and entry step, and it has been postulated that the F protein undergoes complex refolding during this process. Here we report the crystal structure of the parainfluenza virus 5 F protein in its prefusion conformation, stabilized by the addition of a c ...[more]
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