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Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.

ABSTRACT: PURPOSE:Endothelial protein C receptor (EPCR) is expressed mainly in endothelial cells and is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. We assessed whether haplotypes in the EPCR gene modify the risk of severe sepsis and/or septic shock (SS/SS) development in critically ill patients. METHODS:Three polymorphisms in the EPCR gene were genotyped in 389 Caucasian critically ill patients, hospitalized in the intensive care units of two major hospitals in Athens, Greece. Multivariate logistic regression analysis controlling for age, acute physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, sex, and diagnosis was performed to determine the effect of haplotypes H1 and H3 in the EPCR gene on the development of SS/SS. RESULTS:H2 carriers versus all other genotypes combined had a nonsignificant excess of SS/SS (p = 0.087). SS/SS occurred in 38.8% of critically ill patients carrying minor alleles belonging to both H1 and H3 haplotypes, in 58.0% of H1 carriers, 64.3% of H3 carriers, and 65.2% of patients carrying all common alleles (H2). Compared with H2 carriers, the odds ratios (OR) for developing SS/SS were 0.34 [95% confidence interval (CI) 0.16-0.76, p = 0.008] for simultaneous H1 and H3 carriers, 0.65 (95% CI 0.37-1.13, p = 0.123) for H1 carriers, and 0.82 (95 % CI 0.39-1.70, p = 0.590) for H3 carriers. CONCLUSIONS:Our results indicate that simultaneous carriers of minor alleles belonging to both the H1 and H3 haplotypes may be at reduced risk of developing SS/SS in this cohort of critically ill patients.

SUBMITTER: Vassiliou AG

PROVIDER: S-EPMC7095157 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.

Vassiliou Alice G AG Maniatis Nikolaos A NA Kotanidou Anastasia A Kallergi Marina M Karystinaki Foteini S FS Letsiou Eleftheria E Glynos Constantinos C Kopterides Petros P Vassiliadi Dimitra D Nikitas Nikitas N Dimopoulou Ioanna I Armaganidis Apostolos A Orfanos Stylianos E SE

Intensive care medicine 20130724 10

<h4>Purpose</h4>Endothelial protein C receptor (EPCR) is expressed mainly in endothelial cells and is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. We assessed whether haplotypes in the EPCR gene modify the risk of severe sepsis and/or septic shock (SS/SS) development in critically ill patients.<h4>Methods</h4>Three polymorphisms in the EPCR gene were genotyped in 389 Caucasian critically ill patients, hospitalized in the intensive care units of two major ...[more]

PMID: 23881209

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Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.

Publications

Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients.

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