Ontology highlight
ABSTRACT:
SUBMITTER: Karimi Abadchi J
PROVIDER: S-EPMC7096182 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
eLife 20200313
A prevalent model is that sharp-wave ripples (SWR) arise 'spontaneously' in CA3 and propagate recent memory traces outward to the neocortex to facilitate memory consolidation there. Using voltage and extracellular glutamate transient recording over widespread regions of mice dorsal neocortex in relation to CA1 multiunit activity (MUA) and SWR, we find that the largest SWR-related modulation occurs in retrosplenial cortex; however, contrary to the unidirectional hypothesis, neocortical activation ...[more]