Ontology highlight
ABSTRACT:
SUBMITTER: Fonseca R
PROVIDER: S-EPMC7096285 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Fonseca Raissa R Beura Lalit K LK Quarnstrom Clare F CF Ghoneim Hazem E HE Fan Yiping Y Zebley Caitlin C CC Scott Milcah C MC Fares-Frederickson Nancy J NJ Wijeyesinghe Sathi S Thompson Emily A EA Borges da Silva Henrique H Vezys Vaiva V Youngblood Benjamin B Masopust David D
Nature immunology 20200217 4
Central memory T (T<sub>CM</sub>) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (T<sub>RM</sub>) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated T<sub>RM</sub> cells rejoined the circulating pool. Epigenetic analyses revealed that T<sub>RM</s ...[more]