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EDN1 gene potentially involved in the development of acute mountain sickness.


ABSTRACT: Previous investigations have indicated that environmental and genetic factors collectively contribute to the development of acute mountain sickness (AMS), but whether the EDN1 gene is involved in AMS remains to be elucidated. A total of 356 healthy male soldiers who had not traveled to high altitudes in the previous 12 months were enrolled in our study. All participants were taken by plane from 500?m (Chengdu in Sichuan Province) to a 3700?m highland (Lhasa) within 2?hours. Clinical data were collected within 24?hours, and pulmonary function parameters were completed simultaneously. Genotypes were obtained by using iMLDR genotyping assays. A total of 237 soldiers (66.57%) presented AMS symptoms, including headache, dizziness, gastrointestinal upset and fatigue. Soldiers with AMS showed an increase in heart rate (HR), plasma tryptophan and serotonin, and a decrease in SaO2, FEV1, PEF, FVC, V75, V50, V25 and MMF (all P?

SUBMITTER: Yu J 

PROVIDER: S-EPMC7096518 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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EDN1 gene potentially involved in the development of acute mountain sickness.

Yu Jie J   Liu Chuan C   Zhang Chen C   Bian ShiZhu S   Yang Jie J   Zhang JiHang J   Gao XuBin X   Qiu YouZhu Y   Huang Lan L  

Scientific reports 20200325 1


Previous investigations have indicated that environmental and genetic factors collectively contribute to the development of acute mountain sickness (AMS), but whether the EDN1 gene is involved in AMS remains to be elucidated. A total of 356 healthy male soldiers who had not traveled to high altitudes in the previous 12 months were enrolled in our study. All participants were taken by plane from 500 m (Chengdu in Sichuan Province) to a 3700 m highland (Lhasa) within 2 hours. Clinical data were co  ...[more]

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