Rosuvastatin alters the genetic composition of the human gut microbiome.
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ABSTRACT:
SUBMITTER: Kummen M
PROVIDER: S-EPMC7096534 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Rosuvastatin alters the genetic composition of the human gut microbiome.
Kummen Martin M Solberg Ole Geir OG Storm-Larsen Christopher C Holm Kristian K Ragnarsson Asgrimur A Trøseid Marius M Vestad Beate B Skårdal Rita R Yndestad Arne A Ueland Thor T Svardal Asbjørn A Berge Rolf K RK Seljeflot Ingebjørg I Gullestad Lars L Karlsen Tom H TH Aaberge Lars L Aukrust Pål P Hov Johannes R JR
Scientific reports 20200325 1
The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the human microbiome is scarce. We aimed to characterize the effect of rosuvastatin on gut microbiome composition and inferred genetic content in stool samples from a randomized controlled trial (n = 66). No taxa were significantly altered by rosuvastatin during the study. However, ...[more]
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