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Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.

ABSTRACT: The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

SUBMITTER: Haveri A 

PROVIDER: S-EPMC7096774 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.

Haveri Anu A   Smura Teemu T   Kuivanen Suvi S   Österlund Pamela P   Hepojoki Jussi J   Ikonen Niina N   Pitkäpaasi Marjaana M   Blomqvist Soile S   Rönkkö Esa E   Kantele Anu A   Strandin Tomas T   Kallio-Kokko Hannimari H   Mannonen Laura L   Lappalainen Maija M   Broas Markku M   Jiang Miao M   Siira Lotta L   Salminen Mika M   Puumalainen Taneli T   Sane Jussi J   Melin Merit M   Vapalahti Olli O   Savolainen-Kopra Carita C  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20200301 11

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid an  ...[more]

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