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Visualization of macromolecular structures.

ABSTRACT: Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

SUBMITTER: O'Donoghue SI

PROVIDER: S-EPMC7097155 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Visualization of macromolecular structures.

O'Donoghue Seán I SI Goodsell David S DS Frangakis Achilleas S AS Jossinet Fabrice F Laskowski Roman A RA Nilges Michael M Saibil Helen R HR Schafferhans Andrea A Wade Rebecca C RC Westhof Eric E Olson Arthur J AJ

Nature methods 20100301 3 Suppl

Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus ...[more]

PMID: 20195256

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