Oncolytic viruses: a new class of immunotherapy drugs.
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ABSTRACT:
SUBMITTER: Kaufman HL
PROVIDER: S-EPMC7097180 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Oncolytic viruses: a new class of immunotherapy drugs.
Kaufman Howard L HL Kohlhapp Frederick J FJ Zloza Andrew A
Nature reviews. Drug discovery 20150901 9
Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour responses through a dual mechanism of action that is dependent on selective tumour cell killing and the induction of systemic anti-tumour immunity. The molecular and cellular mechanisms of action are not fully elucidated but are likely to depend on viral replication within transformed cells, induction of primary cell death, interaction with tumour cell antiviral elements and initiation of innate and adaptive a ...[more]
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