Identification of influenza A nucleoprotein as an antiviral target.
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ABSTRACT:
SUBMITTER: Kao RY
PROVIDER: S-EPMC7097325 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Identification of influenza A nucleoprotein as an antiviral target.
Kao Richard Y RY Yang Dan D Lau Lai-Shan LS Tsui Wayne H W WH Hu Lihong L Dai Jun J Chan Mei-Po MP Chan Che-Man CM Wang Pui P Zheng Bo-Jian BJ Sun Jian J Huang Jian-Dong JD Madar Jason J Chen Guanhua G Chen Honglin H Guan Yi Y Yuen Kwok-Yung KY
Nature biotechnology 20100530 6
Influenza A remains a significant public health challenge because of the emergence of antigenically shifted or highly virulent strains. Antiviral resistance to available drugs such as adamantanes or neuraminidase inhibitors has appeared rapidly, creating a need for new antiviral targets and new drugs for influenza virus infections. Using forward chemical genetics, we have identified influenza A nucleoprotein (NP) as a druggable target and found a small-molecule compound, nucleozin, that triggers ...[more]
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