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An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review.

ABSTRACT: A 50-year-old male presented to our hospital complaining of dry cough and slight fever. A chest CT scan showed a mass in the right upper lung lobe, pleural effusion on both sides, and multiple liver tumors. He was diagnosed with small cell lung cancer (SCLC), and then antitumor chemotherapy was started. Thereafter, his condition deteriorated rapidly, and died 2 days later. An autopsy revealed that the cause of death was ruptured liver metastases. SCLC is a highly invasive disease and often metastasizes to the liver, but the rupture of liver metastases is rare. Clinical features and imaging findings were of a great help in diagnosing ruptured hepatic metastasis. Physicians need to pay attention to this condition, especially after chemotherapy has initiated.

SUBMITTER: Goto Y

PROVIDER: S-EPMC7097517 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review.

Goto Yuki Y Tobino Kazunori K Yoshimine Kohei K Sueyasu Takuto T Okahisa Masanobu M Sakabe Mitsukuni M Tsuruno Kosuke K

Respiratory medicine case reports 20200319

A 50-year-old male presented to our hospital complaining of dry cough and slight fever. A chest CT scan showed a mass in the right upper lung lobe, pleural effusion on both sides, and multiple liver tumors. He was diagnosed with small cell lung cancer (SCLC), and then antitumor chemotherapy was started. Thereafter, his condition deteriorated rapidly, and died 2 days later. An autopsy revealed that the cause of death was ruptured liver metastases. SCLC is a highly invasive disease and often metas ...[more]

PMID: 32257791

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Project description:Introduction and importance: Ruptured esophageal varices are fatal and cause haemorrhagic shock and consequently death if no immediate intervention is instituted to arrest bleeding. The role of forensic pathologists in investigating cases of sudden unexpected deaths is of paramount importance. Upon medico-legal work ups by forensic pathologists, autopsy would shed light to the exact cause of death as to whether it is natural or unnatural. Case presentation We are reporting an unusual case of an elderly man with alcoholic liver cirrhosis who succumbed to sudden death following ruptured esophageal varices which led to haemorrhagic shock. Clinical discussion Clinical autopsy was carried out to establish the cause of death. Tissue sections from the healed pathologically fractured bone, liver, prostate and esophagus were taken for histological evaluation. The bone tissue showed relative reparative changes and the prostate tissue showed hyperplasia of both stroma and epithelial components. The tissue from the esophagus showed proliferating distended, engorged vascular structures and some were thrombosed (photograph 3). Liver biopsy showed destruction of the normal liver parenchyma by both micro and macro nodular formation which was marked by the thick broad fibrous bands. A conclusive diagnosis of hemorrhagic shock secondary to ruptured esophageal varices caused by alcoholic liver cirrhosis was established as the cause of death. Conclusion Esophageal varices can be the likely cause of sudden death upon rupturing. Rupturing of esophageal varices in individuals with a known long-standing history of alcoholism must always be considered in order to prevent haemorrhagic shock from ensuing. Highlights • Ruptured esophageal varices are fatal and cause haemorrhagic shock.• Decompensated liver cirrhosis is a common cause of upper gastrointestinal bleeding.• Esophageal varices represent the most important complications of portal hypertension.• Alcoholic liver cirrhosis is associated with a significantly higher risk of variceal bleeding than from other causes.• Poor liver function contributes to abnormalities in coagulation.

Dataset Information

An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review.

Publications

An autopsy case of ruptured liver metastases from small cell lung cancer: A case report and literature review.

Similar Datasets

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