STAT4: an immunoregulator contributing to diverse human diseases.
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ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC7097918 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
STAT4: an immunoregulator contributing to diverse human diseases.
Yang Chou C Mai Haoming H Peng Jinxin J Zhou Bin B Hou Jinlin J Jiang Deke D
International journal of biological sciences 20200305 9
Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression. We reviewed the essential role played by STAT4 in a wide variety of cells and the pathogenesis of diverse human diseases, especially many kinds of autoimmune and inflammatory diseases, via activation by different cytokine ...[more]
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