MiR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7097947 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer.
Zhang Juan J Xing Ling L Xu Hongwei H Wang Kaixuan K She Junjun J Shi Feiyu F Wu Hongyu H Sun Yongjie Y Gao Jun J He Shuixiang S
Journal of Cancer 20200305 11
Gastric cancer (GC) exhibits a poor prognosis due to extensive invasion and lymphatic metastasis in the advanced stage. In this study, we firstly found that the expression of miR-204-5p markedly decreased in GC patients' tissue and serum, especially in GC with lymphatic metastasis. And ROC analysis showed miR-204-5p also served as a predicted factor for the lymphatic metastasis of GC. CXCL12 and CXCR4 were predicted and confirmed as the functional targets of miR-204-5p by Targetscan analysis, du ...[more]
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