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Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

ABSTRACT: Several chronic viral infections (such as HIV and hepatitis C virus) are highly prevalent and are a serious health risk. The adaptation of animal viruses to the human host, as recently exemplified by influenza viruses and the severe acute respiratory syndrome coronavirus, is also a continuous threat. There is a high demand, therefore, for new antiviral lead compounds and novel therapeutic concepts. In this Review, an original therapeutic concept for suppressing enveloped viruses is presented that is based on a specific interaction of carbohydrate-binding agents (CBAs) with the glycans present on viral-envelope glycoproteins. This approach may also be extended to other pathogens, including parasites, bacteria and fungi.

SUBMITTER: Balzarini J

PROVIDER: S-EPMC7098186 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

Balzarini Jan J

Nature reviews. Microbiology 20070801 8

Several chronic viral infections (such as HIV and hepatitis C virus) are highly prevalent and are a serious health risk. The adaptation of animal viruses to the human host, as recently exemplified by influenza viruses and the severe acute respiratory syndrome coronavirus, is also a continuous threat. There is a high demand, therefore, for new antiviral lead compounds and novel therapeutic concepts. In this Review, an original therapeutic concept for suppressing enveloped viruses is presented tha ...[more]

PMID: 17632570

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