Ontology highlight
ABSTRACT:
SUBMITTER: Morgan BP
PROVIDER: S-EPMC7098197 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nature reviews. Drug discovery 20151023 12
The complement system is a key innate immune defence against infection and an important driver of inflammation; however, these very properties can also cause harm. Inappropriate or uncontrolled activation of complement can cause local and/or systemic inflammation, tissue damage and disease. Complement provides numerous options for drug development as it is a proteolytic cascade that involves nine specific proteases, unique multimolecular activation and lytic complexes, an arsenal of natural inhi ...[more]