Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.

ABSTRACT: BACKGROUND:Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent. AIM:To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14?years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/METHODS:We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1?year-old vs. children 1-14?years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14?years), and recruitment time period. RESULTS:Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ?40-year-old (OR?=?6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year. CONCLUSIONS:An increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.

SUBMITTER: Panagopoulou P 

PROVIDER: S-EPMC7098424 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature