Altered Interactions Among Resting-State Networks in Individuals with Obesity.
Ontology highlight
ABSTRACT: Objective
The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting-state networks involved in salience, executive control, and interoception in participants with obesity (OB).Methods
Using resting-state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting-state networks in 35 OB and 35 normal-weight controls (NW) were investigated.Results
Compared with NW, OB showed reduced FC strength in the ventromedial prefrontal cortex and posterior cingulate cortex/precuneus within the default-mode network, dorsal anterior cingulate cortex within the salience network (SN), bilateral dorsolateral prefrontal cortex-angular gyrus within the frontoparietal network (FPN), and increased FC strength in the insula (INS) (Pfamilywise error ?ConclusionsAlterations in FC within and interactions between the SN, default-mode network, and FPN might contribute to the high incentive value of food (craving), lack of control of overeating (compulsive overeating), and increased awareness of hunger (impaired interoception) in OB.
SUBMITTER: Ding Y
PROVIDER: S-EPMC7098432 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Altered Interactions Among Resting-State Networks in Individuals with Obesity.
Ding Yueyan Y Ji Gang G Li Guanya G Zhang Wenchao W Hu Yang Y Liu Lei L Wang Yuanyuan Y Hu Chunxin C von Deneen Karen M KM Han Yu Y Cui Guangbin G Wang Huaning H Wiers Corinde E CE Manza Peter P Tomasi Dardo D Volkow Nora D ND Nie Yongzhan Y Wang Gene-Jack GJ Zhang Yi Y
Obesity (Silver Spring, Md.) 20200301 3
<h4>Objective</h4>The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting-state networks involved in salience, executive control, and interoception in participants with obesity (OB).<h4>Methods</h4>Using resting-state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting-state networks in 35 OB and 35 normal-weight controls (NW) were investigated.<h ...[more]
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