Ontology highlight
ABSTRACT:
SUBMITTER: Pottorf TS
PROVIDER: S-EPMC7098713 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Pottorf Tana S TS Fagan Micaella P MP Burkey Bryan F BF Cho David J DJ Vath James E JE Tran Pamela V PV
JCI insight 20200130 2
The ciliopathies Bardet-Biedl syndrome and Alström syndrome are genetically inherited pleiotropic disorders with hyperphagia and obesity as primary clinical features. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and clinical studies to reduce food intake, body weight, and adiposity. Here, we investigated the effects of MetAP2i administration in a mouse model of ciliopathy produced by conditional deletion of the Thm1 gene in adulthood. Thm1 conditional knockout ...[more]