Ontology highlight
ABSTRACT:
SUBMITTER: Sakaue S
PROVIDER: S-EPMC7099015 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Sakaue Saori S Hirata Jun J Kanai Masahiro M Suzuki Ken K Akiyama Masato M Lai Too Chun C Arayssi Thurayya T Hammoudeh Mohammed M Al Emadi Samar S Masri Basel K BK Halabi Hussein H Badsha Humeira H Uthman Imad W IW Saxena Richa R Padyukov Leonid L Hirata Makoto M Matsuda Koichi K Murakami Yoshinori Y Kamatani Yoichiro Y Okada Yukinori Y
Nature communications 20200326 1
The diversity in our genome is crucial to understanding the demographic history of worldwide populations. However, we have yet to know whether subtle genetic differences within a population can be disentangled, or whether they have an impact on complex traits. Here we apply dimensionality reduction methods (PCA, t-SNE, PCA-t-SNE, UMAP, and PCA-UMAP) to biobank-derived genomic data of a Japanese population (n = 169,719). Dimensionality reduction reveals fine-scale population structure, conspicuou ...[more]