Ontology highlight
ABSTRACT:
SUBMITTER: Ipponjima S
PROVIDER: S-EPMC7099034 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ipponjima Sari S Umino Yuki Y Nagayama Masaharu M Denda Mitsuhiro M
Scientific reports 20200326 1
The stratum corneum plays a crucial role in epidermal barrier function. Various changes occur in granular cells at the uppermost stratum granulosum during cornification. To understand the temporal details of this process, we visualized the cell shape and organelles of cornifying keratinocytes in a living human epidermal equivalent model. Three-dimensional time-lapse imaging with a two-photon microscope revealed that the granular cells did not simply flatten but first temporarily expanded in thic ...[more]