Ontology highlight
ABSTRACT:
SUBMITTER: Crompe B
PROVIDER: S-EPMC7099038 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Crompe Brice de la B Aristieta Asier A Leblois Arthur A Elsherbiny Salma S Boraud Thomas T Mallet Nicolas P NP
Nature communications 20200326 1
The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered following the loss of dopamine in Parkinson's disease (PD). The neural circuit dysfunctions associated with PD include spike-rate alteration concomitant with excessive oscillatory spike-synchronization in the beta frequency range (12-30 Hz). Which neuronal circuits orchestrate and propagate these abnormal neural dynamics in CBG remains unknown. In this work, we combine in vivo electrophysiological recording ...[more]