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Angiogenesis in Tissue Engineering: As Nature Intended?

ABSTRACT: Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

SUBMITTER: Mastrullo V

PROVIDER: S-EPMC7099606 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo Valeria V Cathery William W Velliou Eirini E Madeddu Paolo P Campagnolo Paola P

Frontiers in bioengineering and biotechnology 20200320

Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic pro ...[more]

PMID: 32266227

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