Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC7100716 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Huang Weijiao W Masureel Matthieu M Qu Qianhui Q Janetzko John J Inoue Asuka A Kato Hideaki E HE Robertson Michael J MJ Nguyen Khanh C KC Glenn Jeffrey S JS Skiniotis Georgios G Kobilka Brian K BK
Nature 20200116 7798
Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs), thereby preventing G-protein coupling, triggering receptor internalization and affecting various downstream signalling pathways<sup>1,2</sup>. Although there is a wealth of structural information detailing the interactions between GPCRs and G proteins, less is known about how arrestins engage GPCRs. Here we report a cryo-electron microscopy structure of full-length human neurotensin receptor 1 (NTSR1) in comple ...[more]