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Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease.

ABSTRACT: This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardiovascular (CV) death, acute myocardial infarction (AMI), angina-related hospitalizations, and hospitalizations for heart failure. The all-cause mortality rate was significantly higher in the high hsCK-MB group compared to the low hsCK-MB group (4.64% vs. 1.88%, p?=?0.0026). After adjusting for baseline covariates, there were no significant differences for the secondary outcomes. H-FABP (?4.226?ng/mL) was the best predictor for all-cause mortality (HR?=?2.68, 95% CI?=?1.28-5.62, p?=?0.009) and CV death (HR?=?6.84, 95% CI?=?1.89-22.14, p?=?0.003). The high NT-proBNP group had a higher AMI-related hospitalization rate (HR?=?1.91, 95% CI?=?1.00-3.65, p?=?0.05). Neither the addition of hsCK-MB to any other markers nor combinations of the three markers improved the prognostic significance of CV outcomes. In conclusion, hsCK-MB was an independent predictor for all-cause mortality but not CV outcomes in patients with SCHD. Combination of hsCK-MB, H-FABP and NT-proBNP failed to improve the prognostic power for all-cause mortality or CV outcomes.

SUBMITTER: Wu YW

PROVIDER: S-EPMC7101408 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease.

Wu Yen-Wen YW Ho Sing Kong SK Tseng Wei-Kung WK Yeh Hung-I HI Leu Hsin-Bang HB Yin Wei-Hsian WH Lin Tsung-Hsien TH Chang Kuan-Cheng KC Wang Ji-Hung JH Wu Chau-Chung CC Chen Jaw-Wen JW

Scientific reports 20200327 1

This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardio ...[more]

PMID: 32221337

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Dataset Information

Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease.

Publications

Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease.

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