A hybrid stochastic model of the budding yeast cell cycle.
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ABSTRACT:
SUBMITTER: Ahmadian M
PROVIDER: S-EPMC7101447 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
A hybrid stochastic model of the budding yeast cell cycle.
Ahmadian Mansooreh M Tyson John J JJ Peccoud Jean J Cao Yang Y
NPJ systems biology and applications 20200327 1
The growth and division of eukaryotic cells are regulated by complex, multi-scale networks. In this process, the mechanism of controlling cell-cycle progression has to be robust against inherent noise in the system. In this paper, a hybrid stochastic model is developed to study the effects of noise on the control mechanism of the budding yeast cell cycle. The modeling approach leverages, in a single multi-scale model, the advantages of two regimes: (1) the computational efficiency of a determini ...[more]
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