Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC7102427 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Yang Zhengfeng Z Yan Hui H Dai Wentao W Jing Ji J Yang Yihu Y Mahajan Sahil S Zhou Yubin Y Li Weikai W Macaubas Claudia C Mellins Elizabeth D ED Shih Chien-Cheng CC Fitzpatrick James A J JAJ Faccio Roberta R
Journal of autoimmunity 20190422
Store-operated calcium entry (SOCE) modulates cytosolic calcium in multiple cells. Endoplasmic reticulum (ER)-localized STIM1 and plasma membrane (PM)-localized ORAI1 are two main components of SOCE. STIM1:ORAI1 association requires STIM1 oligomerization, its re-distribution to ER-PM junctions, and puncta formation. However, little is known about the negative regulation of these steps to prevent calcium overload. Here, we identified Tmem178 as a negative modulator of STIM1 puncta formation in my ...[more]