Dataset Information

Evidence of prenatal toxicity of herbal based indigenous formulations for sex selection in rat models.

ABSTRACT: Indigenous preparations(IPs) for a male child is reported from some parts of India. The present study aims to explore the effects of IPs for sex selection or sex selection drugs (SSDs) on pregnancy outcomes in rat models. SSDs contain Bryonia laciniosa, Quercus infectoria and Putranjiva roxburghii along with other ingredients.

Methods

An experimental design with successfully mated female rats were randomized into control and treatment groups. Phase 1 had 2 interventional arms while phase 2 had 3 interventional arms (12 rats/arm) besides control arm. In phase-1, pregnant females were dosed two SSDs(1000?mg/kg) on gestation days 1-5 whereas, in phase-2, on gestation days 6-19 to correlate the effect of the SSDs (500/1000/1500?mg/kg) consumption during different stages of pregnancy. Pregnant females were observed for clinical signs following treatment. The rats were sacrificed one day before expected day of delivery for evaluation. Pregnancy rate, gestation index, number of corpora lutea, and litter size were assessed. Foetuses were examined for sex, skeletal and soft tissue alterations.

Discussion and conclusion

In phase 1, no appreciable findings were there with SSD exposure. In phase 2, intrauterine growth and survival of foetuses were affected when SSDs were administered during organogenesis period. Decreased number of live foetuses and increased incidence of early and late resorption, reduced fetal growth with significant alteration in skeleton and viscera were found in treatment groups in a dose-dependent manner. This correlates well with findings from observational studies in pregnant women. However, such treatment at any dose did not effect sex differentiation.

SUBMITTER: Bandyopadhyay Neogi S

PROVIDER: S-EPMC7102661 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Evidence of prenatal toxicity of herbal based indigenous formulations for sex selection in rat models.

Bandyopadhyay Neogi Sutapa S Roy Dilip Kumar DK Sachdeva Anand Kamal AK Sharma Rashmi R Gupta Rakesh R Ganguli Abhijit A

Journal of traditional and complementary medicine 20190917 1

Indigenous preparations(IPs) for a male child is reported from some parts of India. The present study aims to explore the effects of IPs for sex selection or sex selection drugs (SSDs) on pregnancy outcomes in rat models. SSDs contain <i>Bryonia laciniosa, Quercus infectoria and Putranjiva roxburghii</i> along with other ingredients.<h4>Methods</h4>An experimental design with successfully mated female rats were randomized into control and treatment groups. Phase 1 had 2 interventional arms while ...[more]

PMID: 32292714

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Project description:Traditional knowledge about the use of medicinal plants for herbal drinks (HDs) is not well documented in the Azad Kashmir region despite their widespread use. This study highlights the taxonomic diversity and traditional knowledge on medicinal plants used for HDs while examining the diversity of diseases treated with HDs in the study area.Individual discussions were conducted with 255 informants (84 women and 171 men). Data gathered included (i) informant age and gender, (ii) HD species and respective plant parts used, (iii) health disorders treated, and (iv) mode of preparation and utilizations. Quantitative ethnobotanical indices including relative frequency of citation (RFC), informant consensus factor (ICF), and use value (UV) were used for data analyses.Altogether, 73 medicinal plants belonging to 40 families and 66 genera were reported to be used in HD preparations, with Asteraceae being the richest family. The average number of HD species cited was 9.09?±?0.17 per informant and did not vary either by age or gender. In addition, men and women, and adults and the young used the same pool of species (dissimilarity nearly zero). The most used plant parts were leaves (20.00%), roots (17.25%), and fruits (16.47%). Based on UV, the top five most used species were Valeriana jatamansi, Isodon rugosus, Onopordum acanthium, Acacia nilotica, and Viola canescens; and the UV was similar among gender and age categories too. The most utilized herbal preparation forms included decoctions, infusions, and tea. One hundred and eleven diseases grouped into 13 ailment categories were reported to be cured using HDs. The main category of disease treated with HDs was gastrointestinal (GIT) disorders (RFC?=?17.43%). Relatively few species were used by a large proportion of informants for each category of ailment (ICF???0.60). Only one species was used for "glandular disorders" and "eye diseases" (ICF?=?1). A novelty of about 22% (16 species) was recorded for HD species in the present work.The diversity of medicinal plant species used as HDs and the associated traditional knowledge are of considerable value to the indigenous communities of the Azad Kashmir region. Therefore, there is a need for conservation and preservation of medicinal HD species as well as the wealth of indigenous knowledge. The conservation effort should be high for species in the ailments categories glandular disorders and eye diseases. The therapeutic uses of HDs have provided basic data for further research focused on phytochemical and pharmacological studies and conservation of the most important species.

Dataset Information

Evidence of prenatal toxicity of herbal based indigenous formulations for sex selection in rat models.

Methods

Discussion and conclusion

Publications

Evidence of prenatal toxicity of herbal based indigenous formulations for sex selection in rat models.

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