Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC7102993 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chen Xi X Su Shichen S Chen Yiqing Y Gao Yanqing Y Li Yangyang Y Shao Zhiwei Z Zhang Yixi Y Shao Qiyuan Q Liu Hehua H Li Jixi J Ma Jinbiao J Gan Jianhua J
Nucleic acids research 20200401 6
NrS-1 is the first known phage that can infect Epsilonproteobacteria, one of the predominant primary producers in the deep-sea hydrothermal vent ecosystems. NrS-1 polymerase is a multidomain enzyme and is one key component of the phage replisome. The N-terminal Prim/Pol and HBD domains are responsible for DNA polymerization and de novo primer synthesis activities of NrS-1 polymerase. However, the structure and function of the C-terminus (CTR) of NrS-1 polymerase are poorly understood. Here, we r ...[more]