Ontology highlight
ABSTRACT:
SUBMITTER: Haqshenas G
PROVIDER: S-EPMC7103279 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Virology 20061109 1
The p7 protein of hepatitis C virus (HCV) functions as an ion channel in planar lipid bilayers, and its function is vital for the virus life cycle. In this study, we replaced either the entire or partial p7 of genotype 2a (strain JFH1), an HCV strain that replicates and produces virus progeny in vitro, with the corresponding regions of the p7 protein from genotype 1b (Australian isolate, HCV-A). Compared to wild type, the chimeric viruses reached their peak of infectivity with a delay but they p ...[more]