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Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila.

ABSTRACT: Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was reduced. When we measured the expression levels of AMP genes during aging, those were getting increased in the control flies but reduced in MRS inhibition flies agedependently. Interestingly, in the germ-free condition, the maximum lifespan was increased in MRS inhibition flies compared with that of the conventional condition. These findings suggest that the lifespan of MRS inhibition flies is reduced due to the down-regulated AMPs expression in Drosophila.

SUBMITTER: Suh YS

PROVIDER: S-EPMC7103878 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila.

Suh Yoon Seok YS Yeom Eunbyul E Nam Jong-Woo JW Min Kyung-Jin KJ Lee Jeongsoo J Yu Kweon K

Molecules and cells 20200301 3

Methionyl-tRNA synthetase (MRS) is essential for translation. MRS mutants reduce global translation, which usually increases lifespan in various genetic models. However, we found that MRS inhibited Drosophila reduced lifespan despite of the reduced protein synthesis. Microarray analysis with MRS inhibited Drosophila revealed significant changes in inflammatory and immune response genes. Especially, the expression of anti-microbial peptides (AMPs) genes was redu ...[more]

PMID: 31940717

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