Ontology highlight
ABSTRACT:
SUBMITTER: Chhatbar C
PROVIDER: S-EPMC7103936 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Chhatbar Chintan C Detje Claudia N CN Grabski Elena E Borst Katharina K Spanier Julia J Ghita Luca L Elliott David A DA Jordão Marta Joana Costa MJC Mueller Nora N Sutton James J Prajeeth Chittappen K CK Gudi Viktoria V Klein Michael A MA Prinz Marco M Bradke Frank F Stangel Martin M Kalinke Ulrich U
Cell reports 20181001 1
In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumu ...[more]