Cerebellar plasticity and associative memories are controlled by perineuronal nets.
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ABSTRACT:
SUBMITTER: Carulli D
PROVIDER: S-EPMC7104182 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Cerebellar plasticity and associative memories are controlled by perineuronal nets.
Carulli Daniela D Broersen Robin R de Winter Fred F Muir Elizabeth M EM Mešković Maja M de Waal Matthijs M de Vries Sharon S Boele Henk-Jan HJ Canto Cathrin B CB De Zeeuw Chris I CI Verhaagen Joost J
Proceedings of the National Academy of Sciences of the United States of America 20200309 12
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When ...[more]
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