Ontology highlight
ABSTRACT:
SUBMITTER: Xiong X
PROVIDER: S-EPMC7104313 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Xiong Xiao X Ke Xiurong X Wang Lu L Yao Zhimeng Z Guo Yi Y Zhang Xianyang X Chen Yuping Y Pang Chi Pui CP Schally Andrew V AV Zhang Hao H
Proceedings of the National Academy of Sciences of the United States of America 20200310 12
The extrahypothalamic growth hormone-releasing hormone (GHRH) and its cognate receptors (GHRH-Rs) and splice variants are expressed in a variety of cancers. It has been shown that the pituitary type of GHRH-R (pGHRH-R) mediates the inhibition of tumor growth induced by GHRH-R antagonists. However, GHRH-R antagonists can also suppress some cancers that do not express pGHRH-R, yet the underlying mechanisms have not been determined. Here, using human esophageal squamous cell carcinoma (ESCC) as a m ...[more]