Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience.

ABSTRACT:

Background

Leptomeningeal dissemination (LD) in adults is an exceedingly rare complication of low-grade neuroepithelial CNS tumors (LGNs). We aimed to determine relative incidence, clinical presentation, and predictors of outcome.

Methods

We searched the quality control database of the Section of Neuro-Oncology, Yale Cancer Center, for patients with LGN (WHO grade I/II) seen between 2002 and 2017. For cases complicated by LD, we recorded demographics, clinical signs, histopathological diagnosis, and imaging findings. A comprehensive literature review was performed.

Results

Eleven consecutive patients with LD were identified, representing 2.3% of individuals with LGN seen at our institution between 2002 and 2017 (n = 475). Ependymoma was the predominant histological en

SUBMITTER: Karschnia P 

PROVIDER: S-EPMC7104875 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature