Ontology highlight
ABSTRACT:
SUBMITTER: Pogan R
PROVIDER: S-EPMC7104913 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Pogan Ronja R Schneider Carola C Reimer Rudolph R Hansman Grant G Uetrecht Charlotte C
Journal of physics. Condensed matter : an Institute of Physics journal 20180201 6
Noroviruses are the main cause of viral gastroenteritis with new variants emerging frequently. There are three norovirus genogroups infecting humans. These genogroups are divided based on the sequence of their major capsid protein, which is able to form virus-like particles (VLPs) when expressed recombinantly. VLPs of the prototypical GI.1 Norwalk virus are known to disassemble into specific capsid protein oligomers upon alkaline treatment. Here, native mass spectrometry and electron microscopy ...[more]