Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC7104992 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Xie Jiazheng J Li Yang Y Shen Xurui X Goh Geraldine G Zhu Yan Y Cui Jie J Wang Lin-Fa LF Shi Zheng-Li ZL Zhou Peng P
Cell host & microbe 20180222 3
Compared with terrestrial mammals, bats have a longer lifespan and greater capacity to co-exist with a variety of viruses. In addition to cytosolic DNA generated by these viral infections, the metabolic demands of flight cause DNA damage and the release of self-DNA into the cytoplasm. However, whether bats have an altered DNA sensing/defense system to balance high cytosolic DNA levels remains an open question. We demonstrate that bats have a dampened interferon response due to the replacement of ...[more]