Ontology highlight
ABSTRACT:
SUBMITTER: Harris-Bookman S
PROVIDER: S-EPMC7105259 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Harris-Bookman Sarah S Mathios Dimitrios D Martin Allison M AM Xia Yuanxuan Y Kim Eileen E Xu Haiying H Belcaid Zineb Z Polanczyk Magdalena M Barberi Theresa T Theodros Debebe D Kim Jennifer J Taube Janis M JM Burger Peter C PC Selby Mark M Taitt Corina C Korman Alan A Ye Xiaobu X Drake Charles G CG Brem Henry H Pardoll Drew M DM Lim Michael M
International journal of cancer 20180924 12
Like in many tumor types, immunotherapy is currently under investigation to assess its potential efficacy in glioblastoma patients. Trials are under way to assess the efficacy of new immune checkpoint inhibitors including anti-PD-1 or CTLA4. We here investigate the expression and efficacy of a novel immune-checkpoint inhibitor, called LAG-3. We show that LAG-3 is expressed in human glioblastoma samples and in a mouse glioblastoma model we show that knock out or LAG-3 inhibition with a blocking a ...[more]