Ontology highlight
ABSTRACT:
SUBMITTER: Steinberg G
PROVIDER: S-EPMC7105494 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200330 1
The emerging resistance of crop pathogens to fungicides poses a challenge to food security and compels discovery of new antifungal compounds. Here, we show that mono-alkyl lipophilic cations (MALCs) inhibit oxidative phosphorylation by affecting NADH oxidation in the plant pathogens Zymoseptoria tritici, Ustilago maydis and Magnaporthe oryzae. One of these MALCs, consisting of a dimethylsulfonium moiety and a long alkyl chain (C<sub>18</sub>-SMe<sub>2</sub><sup>+</sup>), also induces production ...[more]