Dataset Information

Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features.

ABSTRACT: Bacteriophage is a type of virus that could infect the host bacteria. They have been applied in the treatment of pathogenic bacterial infection. Phage enzymes and hydrolases play the most important role in the destruction of bacterial cells. Correctly identifying the hydrolases coded by phage is not only beneficial to their function study, but also conducive to antibacteria drug discovery. Thus, this work aims to recognize the enzymes and hydrolases in phage. A combination of different features was used to represent samples of phage and hydrolase. A feature selection technique called analysis of variance was developed to optimize features. The classification was performed by using support vector machine (SVM). The prediction process includes two steps. The first step is to identify phage enzymes. The second step is to determine whether a phage enzyme is hydrolase or not. The jackknife cross-validated results showed that our method could produce overall accuracies of 85.1 and 94.3%, respectively, for the two predictions, demonstrating that the proposed method is promising.

SUBMITTER: Li HF

PROVIDER: S-EPMC7105632 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features.

Li Hong-Fei HF Wang Xian-Fang XF Tang Hua H

Frontiers in bioengineering and biotechnology 20200324

Bacteriophage is a type of virus that could infect the host bacteria. They have been applied in the treatment of pathogenic bacterial infection. Phage enzymes and hydrolases play the most important role in the destruction of bacterial cells. Correctly identifying the hydrolases coded by phage is not only beneficial to their function study, but also conducive to antibacteria drug discovery. Thus, this work aims to recognize the enzymes and hydrolases in phage. A combination of different features ...[more]

PMID: 32266225

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Project description:BackgroundTumor deposits (TDs) are associated with poor prognosis in rectal cancer (RC). This study aims to develop and validate a deep learning (DL) model incorporating T2-MR image and clinical factors for the preoperative prediction of TDs in RC patients.Methods and methodsA total of 327 RC patients with pathologically confirmed TDs status from January 2016 to December 2019 were retrospectively recruited, and the T2-MR images and clinical variables were collected. Patients were randomly split into a development dataset (n = 246) and an independent testing dataset (n = 81). A single-channel DL model, a multi-channel DL model, a hybrid DL model, and a clinical model were constructed. The performance of these predictive models was assessed by using receiver operating characteristics (ROC) analysis and decision curve analysis (DCA).ResultsThe areas under the curves (AUCs) of the clinical, single-DL, multi-DL, and hybrid-DL models were 0.734 (95% CI, 0.674-0.788), 0.710 (95% CI, 0.649-0.766), 0.767 (95% CI, 0.710-0.819), and 0.857 (95% CI, 0.807-0.898) in the development dataset. The AUC of the hybrid-DL model was significantly higher than the single-DL and multi-DL models (both p < 0.001) in the development dataset, and the single-DL model (p = 0.028) in the testing dataset. Decision curve analysis demonstrated the hybrid-DL model had higher net benefit than other models across the majority range of threshold probabilities.ConclusionsThe proposed hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer.Critical relevance statementThe proposed hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer.Key points• Preoperative non-invasive identification of TDs is of great clinical significance. • The combined hybrid-DL model achieved good predictive efficacy and could be used to predict tumor deposits in rectal cancer. • A preoperative nomogram provides gastroenterologist with an accurate and effective tool.

Dataset Information

Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features.

Publications

Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features.

Similar Datasets

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