Ontology highlight
ABSTRACT:
SUBMITTER: Ye X
PROVIDER: S-EPMC7105721 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ye Xiaolan X Ong Naomi N An Huazhang H Zheng Yuejuan Y
Frontiers in immunology 20200324
The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome duplication, cell proliferation, and apoptosis. Recent studies revealed that NDR1/2 also play important roles in the regulation of infection and inflammation. In this review, we summarized the roles o ...[more]